NFL World Reacts to Patrick Mahomes Suffering an Ugly Knee Injury

Patrick Mahomes suffered a scary knee injury during the Chiefs’ 16-13 loss to the Chargers on Sunday, and the NFL world was in shock.

The loss eliminated Kansas City from the playoffs, but may also have cost the team its quarterback.

Mahomes was injured while rolling to his right to throw a pass away. Los Angeles defensive lineman Da’Shawn Hand grabbed his legs, and Mahomes’s left knee bent awkwardly. He was down on the field and appeared to be in a considerable amount of pain before being helped off the field and back to the locker room.

Video of the play is below.

With their season on the line, Patrick Mahomes goes down with an apparent knee injury. Walks off with assistance.

Gardner Minshew is in as the Chiefs look to tie the game late. pic.twitter.com/xn5ta8XLoc
— Awful Announcing (@awfulannouncing) December 14, 2025

Patrick Mahomes has been helped to the locker room. pic.twitter.com/fYaewY0EVJ
— Bussin' With The Boys (@BussinWTB) December 14, 2025

Pundits, fans, and players from across the NFL world reacted to what could be a devastating injury.

Mahomes is seriously hurt. Left knee. Looks awful.
— Matt Verderame (@MattVerderame) December 14, 2025

I hate injuries shake back 15
— Ty Hill (@cheetah) December 14, 2025

If you are celebrating Mahomes' injury, you are the problem

Prayers up for Pat 🙏
— Karsen 🐎 (@Broncos4six) December 14, 2025

On quite literally the last gasp of the Chiefs' season, Mahomes goes down with a non-contact injury.

A nightmare's nightmare.
— Kent Swanson (@kent_swanson) December 14, 2025

That Mahomes injury sums up the chiefs season perfectly
— Crobin Carol Enthusiast (@CorlekCarmas) December 14, 2025

Man I hope Mahomes' injury isn't as bad as it looked. I may hate having to deal with him but I have a lot of respect for him and the league is way better with him playing
— max (@bingbongbills) December 14, 2025

I love the downfall of the Chiefs, but I am not a fan of Mahomes being injured.

I want Mahomes to suck, but not be out because of injury.
— Cassidy Ace (@cassidyace89) December 14, 2025

There is no word on the severity of the injury, but given that the Chiefs have been eliminated from the playoffs, it would be shocking to see him play again this season.